Reactive species
Human;Rat;Mouse
Antibody type
Polyclonal Antibody
Protein name
Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (SKCa 4) (SKCa4) (IKCa1) (IK1) (KCa3.1) (KCa4) (Putative Gardos channel)
Immunogen
Synthetic Peptide of KCNN4 (SK4) AA range: 177-227
Specificity
KCNN4(SK4) protein(A247) detects endogenous levels of KCNN4(SK4)
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:1000-2000, IHC 1:50-100. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Other name
KCNN4; IK1; IKCA1; KCA4; SK4; Intermediate conductance calcium-activated potassium channel protein 4; SK4; SKCa 4; SKCa4; IKCa1; IK1; KCa3.1; KCa4; Putative Gardos channel
Background
potassium calcium-activated channel subfamily N member 4(KCNN4) Homo sapiens The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008],
Function
function:Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.,induction:Up-regulated by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells.,similarity:Belongs to the potassium channel KCNN family.,subunit:Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6.,tissue specificity:Widely expressed in non-excitable tissues.,
