Reactive species
Human;Rat;Mouse;
Applications
IHC;IF;WB;ELISA
Antibody type
Polyclonal Antibody
Protein name
Rho GTPase-activating protein 23
Immunogen
Synthesized peptide derived from ARHGAP23 . at AA range: 470-550
Specificity
ARHGAP23 Polyclonal Antibody detects endogenous levels of ARHGAP23 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
ARHGAP23; KIAA1501; Rho GTPase-activating protein 23; Rho-type GTPase-activating protein 23
Background
The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008],
Function
function:GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor.,
