Reactive species
Human;Rat;Mouse;
Applications
WB;IHC;IF;ELISA
Protein name
Interleukin-24
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human IL24. AA range:131-180
Specificity
MDA-7 Polyclonal Antibody detects endogenous levels of MDA-7 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
IL24; MDA7; ST16; Interleukin-24; IL-24; Melanoma differentiation-associated gene 7 protein; MDA-7; Suppression of tumorigenicity 16 protein
Background
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
Function
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.,online information:Interleukin-24 entry,similarity:Belongs to the IL-10 family.,tissue specificity:Up-regulated in melanoma cells induced to terminally differentiate.,
