Reactive species
Human;Mouse;Rat
Antibody type
Polyclonal Antibody
Protein name
Beta-1,3-N-acetylglucosaminyltransferase manic fringe
Immunogen
The antiserum was produced against synthesized peptide derived from human MFNG. AA range:61-110
Specificity
Manic Fringe Polyclonal Antibody detects endogenous levels of Manic Fringe protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
MFNG; Beta-1; 3-N-acetylglucosaminyltransferase manic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Background
This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009],
Function
catalytic activity:Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.,function:Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity.,online information:Beta-1,3-N-acetylglucosaminyltransferase manic fringe,online information:GlycoGene database,similarity:Belongs to the glycosyltransferase 31 family.,
