Antibody type
Monoclonal antibodies
Protein name
Teratocarcinoma-derived growth factor 1
Immunogen
Purified recombinant fragment of human Cripto expressed in E. Coli.
Specificity
Cripto Monoclonal Antibody detects endogenous levels of Cripto protein.
Constitute
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process
Affinity purification
Other name
TDGF1; CRIPTO; Teratocarcinoma-derived growth factor 1; Cripto-1 growth factor; CRGF; Epidermal growth factor-like cripto protein CR1
Background
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],
Function
function:Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.,similarity:Contains 1 EGF-like domain.,tissue specificity:Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts.,
