Applications
WB;IHC;IF;ELISA
Antibody type
Monoclonal antibodies
Immunogen
Purified recombinant fragment of human Cerberus expressed in E. Coli.
Specificity
Cerberus Monoclonal Antibody detects endogenous levels of Cerberus protein.
Constitute
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
Purification process
Affinity purification
Other name
CER1; DAND4; Cerberus; Cerberus-related protein; DAN domain family member 4
Background
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008],
Function
function:Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak.,PTM:N-glycosylated.,sequence caution:Translated as Ser.,similarity:Belongs to the DAN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,subunit:Forms monomers and predominantly dimers.,
