Reactive species
Human;Monkey
Antibody type
Monoclonal antibodies
Immunogen
Purified recombinant human CDX2 protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of CDX2 and does not cross-react with related proteins.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb 1:1000 icc 1:100
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Other name
Caudal type homeo box 2;Caudal type homeo box transcription factor 2;Caudal type homeobox 2;Caudal type homeobox protein 2;caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2;CDX 2;CDX 3;CDX-3;Cdx2;CDX2_HUMAN;CDX3;Homeobox protein CDX 2;Homeobox protein CDX-2;Homeobox protein CDX2.
Background
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012],
Function
function:Involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.,PTM:Phosphorylation of Ser-60 mediates the transactivation capacity.,similarity:Belongs to the Caudal homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,
