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Collagen Type IV mouse mAb(ABT165)

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Collagen Type IV mouse mAb(ABT165)

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Product code: YP-Ab-15654

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human; Predict react with Mouse

Applications

IHC,WB

Antibody type

Monoclonal antibodies

Gene Name

COL4A1

Protein name

Collagen Type IV

Dalton（DA）

Immunogen

Synthesized peptide derived from human Collagen Type IV

Specificity

The antibody can specifically recognize human Collagen Type IV protein, collagen types I, II, III and V do not respond to the anbody.

Constitute

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.31% sodium azide.

Source

Mouse, Monoclonal/IgG2b, kappa

Dilution rate

WB 1:1000-2000;IHC-p 1:100-500, IF 1:100-500

Purification process

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration

Stockpile

-20°C/1 year

Other name

Collagen alpha-1(IV) chain [Cleaved into: Arresten]

Background

This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

Function

disease:Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage [MIM:607595]. Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant.,disease:Defects in COL4A1 are a cause of porencephaly type 1 [MIM:175780]; also known as encephaloclastic porencephaly. Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral and results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Inheritance is autosomal dominant.,disease:Defects in COL4A1 are the cause of hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) [MIM:611773]. The clinical renal manifestations include hematuria and bilateral large cysts. Histologic analysis revealed complex bas

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IP

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蛋白免疫印迹（WB) 实验步骤

Collagen Type IV mouse mAb(ABT165)

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Collagen Type IV mouse mAb(ABT165)

Product introduction

Product Details

Customer data and reviews (0)

Citation

Background information

FAQ

Experimental scheme

IP

WB

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