Reactive species
Human; Predict react with Mouse
Antibody type
Monoclonal antibodies
Protein name
Uroplakin III
Immunogen
Synthesized peptide derived from human Uroplakin III
Specificity
The antibody can specifically recognize human Uroplakin III protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.06% sodium azide.
Source
Mouse, Monoclonal/IgG1, Kappa
Dilution rate
IHC-p 1:100-500, IF 1:100-500
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Other name
Uroplakin-3a (UP3a;Uroplakin III;UPIII)
Background
This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009],
Function
disease:Defects in UPK3A are a cause of renal adysplasia [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.,function:Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.,similarity:Belongs to the uroplakin-3 family.,subcellular location:Heterodimer formation
