Reactive species
Human; Predict react with Mouse, Rat
Antibody type
Monoclonal antibodies
Immunogen
Synthesized peptide derived from human PSA
Specificity
The antibody can specifically recognize human PSA protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.59% sodium azide.
Source
Mouse, Monoclonal/IgG2b, Kappa
Dilution rate
IHC-p 1:100-500, WB 1:200-1000, IF 1:100-500
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Other name
Prostate-specific antigen (PSA;EC 3.4.21.77;Gamma-seminoprotein;Seminin;Kallikrein-3;P-30 antigen;Semenogelase)
Background
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Preferential cleavage: -Tyr-|-Xaa-.,function:Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.,online information:Prostate-specific antigen entry,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,
