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Neurofilament mouse mAb(ABT356)

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Neurofilament mouse mAb(ABT356)

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Product code: YP-Ab-15609

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human

Applications

IHC;WB;IF

Antibody type

Monoclonal antibodies

Gene Name

NEFL NF68 NFL

Protein name

Neurofilament

Dalton（DA）

Immunogen

Synthesized peptide derived from human Neurofilament

Specificity

The antibody can specifically recognize human Neurofilament protein, especilaly NF-L protein.

Constitute

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.57% sodium azide.

Source

Mouse, Monoclonal/IgG2b, kappa

Dilution rate

IHC-p 1:100-500, WB 1:200-1000, IF 1:100-500

Purification process

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration

Stockpile

-20°C/1 year

Other name

Neurofilament light polypeptide (NF-L;68 kDa neurofilament protein;Neurofilament triplet L protein)

Background

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008],

Function

caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F (CMT1F) [MIM:607734]. CMT1F is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1F is charac

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IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

Neurofilament mouse mAb(ABT356)

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Neurofilament mouse mAb(ABT356)

Product introduction

Product Details

Customer data and reviews (0)

Citation

Background information

FAQ

Experimental scheme

IP

WB

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