Reactive species
Human; Predict react with Mouse, Rat
Antibody type
Monoclonal antibodies
Immunogen
Synthesized peptide derived from human MUC6
Specificity
This antibody detects endogenous levels of MUC6 at Human
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.171% sodium azide.
Source
Mouse, Monoclonal/IgG1, Kappa
Dilution rate
IHC-p 1:100-500, IF 1:100-500
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Other name
Mucin-6 (MUC-6;Gastric mucin-6)
Background
The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract (summary by Toribara et al., 1993 [PubMed 7680650]).[supplied by OMIM, Dec 2010],
Function
developmental stage:Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation.,function:May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Play an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.,induction:Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors.,polymorphism:The number of repeats is
