Antibody type
Monoclonal antibodies
Immunogen
Synthesized peptide derived from human MUC4
Specificity
The antibody can specifically recognize human MUC4 protein, and has no cross reaction wit MUC2, MUC5AC, MUC6 proteins.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.173% sodium azide.
Source
Mouse, Monoclonal/IgG2a, Kappa
Dilution rate
IHC-p 1:100-500, WB 1:200-1000, IF 1:100-500
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Other name
Mucin-4 (MUC-4;Ascites sialoglycoprotein;ASGP;Pancreatic adenocarcinoma mucin;Testis mucin;Tracheobronchial mucin) [Cleaved into: Mucin-4 alpha chain (Ascites sialoglycoprotein 1;ASGP-1); Mucin-4 beta chain (Ascites sialoglycoprotein 2;ASGP-2)]
Background
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008],
Function
alternative products:Additional isoforms exist,developmental stage:Expressed early in the primitive gut before respiratory and digestive epithelial cells have acquired their tissue and cell specificity. Expressed at the basal surface of the epithelium from week 14 to 26 weeks and then predominantly localized in only parietal cells. Immediately before birth, found in the cytoplasm of the mucous columnar epithelial cells. In the embryo expressed in skin, then disappears late in gestation.,function:May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proli
