Antibody type
Monoclonal antibodies
Immunogen
Synthesized peptide derived from human BOB.1
Specificity
This antibody detects endogenous levels of BOB.1 at Human
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC-p 1:20. IF 1:50-200
Purification process
The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
Other name
POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1;BOB-1;OCA-B;OCT-binding factor 1)
Function
disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.,function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific.,
