Antibody type
Monoclonal antibodies
Protein name
MutS Protein Homolog 2(MSH2)
Immunogen
Synthesized peptide derived from human MutS Protein Homolog 2(MSH2)
Specificity
This antibody detects endogenous levels of MutS Protein Homolog 2(MSH2) at Human
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC-p 1:1500. IF 1:50-200
Purification process
The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
Other name
DNA mismatch repair protein Msh2 (hMSH2;MutS protein homolog 2)
Function
disease:Defects in MSH2 are a cause of Muir-Torre syndrome (MTS) [MIM:158320]. MTS is a rare autosomal dominant disorder characterized by sebaceous neoplasms and visceral malignancy.,disease:Defects in MSH2 are a cause of susceptibility to endometrial cancer [MIM:608089].,disease:Defects in MSH2 are the cause of hereditary non-polyposis colorectal cancer type 1 (HNPCC1) [MIM:120435]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and femal
