Antibody type
Monoclonal antibodies
Gene Name
GSTP1 FAEES3 GST3
Immunogen
Synthesized peptide derived from human GST-Pi
Specificity
This antibody detects endogenous levels of human GST-Pi, TRIS-EDTA of pH9.0 was used for Heat-induced epitope retrieval (HIER)
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-500 WB 1:1000-2000. IF 1:50-200
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Other name
Glutathione S-transferase P (EC 2.5.1.18;GST class-pi;GSTP1-1)
Background
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008],
Function
catalytic activity:RX + glutathione = HX + R-S-glutathione.,function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the GST superfamily. Pi family.,similarity:Contains 1 GST C-terminal domain.,similarity:Contains 1 GST N-terminal domain.,subunit:Homodimer.,
