Reactive species
Human;Mouse;Rat
Antibody type
Monoclonal antibodies
Gene Name
NAPSA NAP1 NAPA
Immunogen
Synthesized peptide derived from human Napsin A
Specificity
This antibody detects endogenous levels of human Napsin A. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH9.0 was highly recommended as antigen repair method in paraffin section
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Mouse, Monoclonal/IgG1, Kappa
Dilution rate
IHC-p 1:100-500. IF 1:50-200
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Other name
Napsin-A (EC 3.4.23.-;Aspartyl protease 4;ASP4;Asp 4;Napsin-1;TA01/TA02)
Background
This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016],
Function
function:May be involved in processing of pneumocyte surfactant precursors.,similarity:Belongs to the peptidase A1 family.,tissue specificity:Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.,
