Reactive species
Human; Predict react with Rat
Antibody type
Monoclonal antibodies
Gene Name
STMN1 C1orf215 LAP18 OP18
Protein name
C1orf215;Lag;LAP 18;LAP18;Leukemia associated phosphoprotein p18;Leukemia-associated phosphoprotein p18;Metablastin;Oncoprotein 18;OP 18;Op18;p18;p19;Phosphoprotein 19;Phosphoprotein p19;pp17;pp19;PR2
Immunogen
Synthesized peptide derived from human Stathmin
Specificity
The antibody can specifically recognize human Stathmin protein. In western blotting of Hela cell lysate, the antibody can label a 17 kDa band corresponding to Stathmin.
Constitute
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
Source
Monoclonal Mouse IgG2a, Kappa
Dilution rate
IHC-p 1:200-400,WB: 500-1000
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Other name
C1orf215;Lag;LAP 18;LAP18;Leukemia associated phosphoprotein p18;Leukemia-associated phosphoprotein p18;Metablastin;Oncoprotein 18;OP 18;Op18;p18;p19;Phosphoprotein 19;Phosphoprotein p19;pp17;pp19;PR22;Pr22 protein;Prosolin;Protein Pr22;SMN;Stathmin;Stathmin1;STMN 1;Stmn1;STMN1_HUMAN
Background
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009],
Function
disease:Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.,function:Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.,PTM:Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at
