Reactive species
Human;Mouse
Antibody type
Polyclonal Antibody
Protein name
Testis-specific serine/threonine-protein kinase 4
Immunogen
The antiserum was produced against synthesized peptide derived from human TSSK4. AA range:211-260
Specificity
TSSK 4 Polyclonal Antibody detects endogenous levels of TSSK 4 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
TSSK4; C14orf20; STK22E; TSSK5; Testis-specific serine/threonine-protein kinase 4; TSK-4; TSSK-4; Testis-specific kinase 4; Serine/threonine-protein kinase 22E
Background
This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-197, potentially by autophosphorylation.,function:May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling.,PTM:Autophosphorylated (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed only in the testis.,
