Reactive species
Human;Mouse;Rat
Antibody type
Polyclonal Antibody
Protein name
Adenosine kinase
Immunogen
The antiserum was produced against synthesized peptide derived from human ADK. AA range:1-50
Specificity
ADK Polyclonal Antibody detects endogenous levels of ADK protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
ADK; Adenosine kinase; AK; Adenosine 5'-phosphotransferase
Background
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],
Function
catalytic activity:ATP + adenosine = ADP + AMP.,cofactor:Binds 3 magnesium ions per subunit.,function:ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.,pathway:Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.,similarity:Belongs to the carbohydrate kinase pfkB family.,subunit:Monomer.,tissue specificity:Widely expressed. Highest level in placenta, liver, muscle and kidney.,
