Reactive species
Human;Mouse;Rat
Applications
IHC;IF;ELISA
Antibody type
Polyclonal Antibody
Protein name
cGMP-dependent protein kinase 2
Immunogen
The antiserum was produced against synthesized peptide derived from human PKG2 around the phosphorylation site of Ser126. AA range:92-141
Specificity
Phospho-cGKII (S126) Polyclonal Antibody detects endogenous levels of cGKII protein only when phosphorylated at S126.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
PRKG2; PRKGR2; cGMP-dependent protein kinase 2; cGK 2; cGK2; cGMP-dependent protein kinase II; cGKII
Background
This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Binding of cGMP results in enzyme activation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 cyclic nucleotide-binding domains.,tissue specificity:Highly concentrated in brain, lung and intestinal mucosa.,
