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ERK1/2 mouse Monoclonal Antibody(1H4)

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ERK1/2 mouse Monoclonal Antibody(1H4)

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Product code: YP-Ab-14263

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human;Rat;Mouse;Fish

Applications

WB;IHC;IF

Antibody type

Monoclonal antibodies

Gene Name

MAPK1/MAPK3

Protein name

MAPK1/MAPK3

Dalton（DA）

44,42kD

Immunogen

Synthetic Peptide of ERK1/2 at AA range of 140-220

Specificity

ERK1/2 protein detects endogenous levels of MAPK1/MAPK3

Constitute

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source

Monoclonal, Mouse

Dilution rate

WB 1:1000-2000, IHC 1:100-200. IF 1:50-200

Purification process

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration

mg/ml

Stockpile

-20°C/1 year

Other name

MAPK1/MAPK3

Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008],

Function

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by tyrosine phosphorylation in response to insulin and NGF.,function:Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).,PTM:Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinas

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ERK1/2 mouse Monoclonal Antibody(1H4)

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ERK1/2 mouse Monoclonal Antibody(1H4)

Product introduction

Product Details

Customer data and reviews (0)

Citation

Background information

FAQ

Experimental scheme

IP

WB

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