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Tyk 2 Monoclonal Antibody

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Tyk 2 Monoclonal Antibody

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Product code: YP-Ab-14194

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human

Applications

WB;ELISA

Antibody type

Monoclonal antibodies

Gene Name

TYK2

Protein name

Non-receptor tyrosine-protein kinase TYK2

Dalton（DA）

Immunogen

Purified recombinant fragment of Tyk 2 expressed in E. Coli.

Specificity

Tyk 2 Monoclonal Antibody detects endogenous levels of Tyk 2 protein.

Constitute

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

Source

Monoclonal, Mouse

Dilution rate

Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification process

Affinity purification

Concentration

Stockpile

-20°C/1 year

Other name

TYK2; Non-receptor tyrosine-protein kinase TYK2

Background

tyrosine kinase 2(TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008],

Function

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also called autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. The syndrome consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.,online information:TYK2 mutation db,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Conta

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IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

Tyk 2 Monoclonal Antibody

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Tyk 2 Monoclonal Antibody

Product introduction

Product Details

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Citation

Background information

FAQ

Experimental scheme

IP

WB

Primary antibodies

Secondary antibodies

Elisa Kit

Biochemical kit

Recombinant protein

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