Reactive species
Human;Rat;Mouse;
Applications
WB;IHC;IF;ELISA
Antibody type
Polyclonal Antibody
Protein name
Immunoglobulin alpha Fc receptor
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human FCAR. AA range:31-80
Specificity
CD89 Polyclonal Antibody detects endogenous levels of CD89 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
FCAR; CD89; Immunoglobulin alpha Fc receptor; IgA Fc receptor; CD89
Background
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
Function
alternative products:Additional isoforms seem to exist,function:Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.,tissue specificity:Differentially expressed between blood and mucosal myeloid cells. Monocytes express isoform A.1, isoform A.2 and isoform A.3 while alveolar macrophages express isoform A.1 and isoform A.2; however they express only one isoform at their surfaces.,
