Antibody type
Polyclonal Antibody
Protein name
EGF-like module-containing mucin-like hormone receptor-like 2
Immunogen
The antiserum was produced against synthesized peptide derived from human EMR2. AA range:765-814
Specificity
EMR2 Polyclonal Antibody detects endogenous levels of EMR2 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
EMR2; EGF-like module-containing mucin-like hormone receptor-like 2; EGF-like module receptor 2; CD antigen CD312
Background
This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012],
Function
alternative products:A number of isoforms are produced. A number of isoforms consisting of various number of EGF-like domains seems to exist. A soluble form due to a frameshift which introduced a stop codon immediately before the first TM domain is also detected,domain:Binding to chondroitin sulfate is mediated by the fourth EGF domain.,domain:The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk.,function:Receptor probably involved in cell attachment.,PTM:Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 5 EGF-like domains.,subunit:Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembr
