Reactive species
Human;Mouse;Rat
Applications
WB;IHC;IF;ELISA
Antibody type
Polyclonal Antibody
Protein name
Nuclear envelope pore membrane protein POM 121
Immunogen
The antiserum was produced against synthesized peptide derived from human POM121. AA range:1197-1246
Specificity
POM121 Polyclonal Antibody detects endogenous levels of POM121 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
POM121; KIAA0618; NUP121; POM121A; Nuclear envelope pore membrane protein POM 121; Nuclear envelope pore membrane protein POM 121A; Nucleoporin Nup121; Pore membrane protein of 121 kDa; POM121B; Putative nuclear envelope pore membrane prote
Background
This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013],
Function
domain:Contains F-X-F-G repeats.,function:Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).,similarity:Belongs to the POM121 family.,subcellular location:Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase.,
