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PDGFRα mouse Monoclonal Antibody(7A3)

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PDGFRα mouse Monoclonal Antibody(7A3)

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Product code: YP-Ab-12960

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human;Rat;Mouse

Applications

IF;IHC

Antibody type

Monoclonal antibodies

Gene Name

PDGFRA

Protein name

PDGFRA

Dalton（DA）

180kD

Immunogen

Synthetic Peptide of PDGFRα at AA range of 1010-1090

Specificity

PDGFRα protein detects endogenous levels of PDGFRA

Constitute

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source

Monoclonal, Mouse

Dilution rate

IF: 1:50-200 IHC 1:100-200

Purification process

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration

mg/ml

Stockpile

-20°C/1 year

Other name

PDGFRA

Background

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012],

Function

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.,function:Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer, and heterodimer with PDGFRB. Interacts with the SH2 domain of SHB via phosphorylated Tyr-720 (By similarity). Interacts with the S

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IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

PDGFRα mouse Monoclonal Antibody(7A3)

Product navigation

PDGFRα mouse Monoclonal Antibody(7A3)

Product introduction

Product Details

Customer data and reviews (0)

Citation

Background information

FAQ

Experimental scheme

IP

WB

Primary antibodies

Secondary antibodies

Elisa Kit

Biochemical kit

Recombinant protein

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