Applications
WB;IHC;IF;ELISA
Antibody type
Monoclonal antibodies
Protein name
Gamma-synuclein
Immunogen
Purified recombinant fragment of Synuclein-γ expressed in E. Coli.
Specificity
Synuclein-γ Monoclonal Antibody detects endogenous levels of Synuclein-γ protein.
Constitute
Purified antibody in PBS containing 0.03% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
Purification process
Affinity purification
Other name
SNCG; BCSG1; PERSYN; PRSN; Gamma-synuclein; Breast cancer-specific gene 1 protein; Persyn; Synoretin; SR
Background
This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010],
Function
disease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions.,function:Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.,PTM:Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.,similarity:Belongs to the synuclein family.,subcellular location:As
