Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Gene Name
AKR1B10 AKR1B11
Immunogen
Synthesized peptide derived from human AK1BA AA range: 124-174
Specificity
This antibody detects endogenous levels of AK1BA at Human
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008],
Function
enzyme regulation:Inhibited by tolrestat.,function:Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.,similarity:Belongs to the aldo/keto reductase family.,tissue specificity:Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.,
