Reactive species
Human; Mouse;Rat
Antibody type
Polyclonal Antibody
Gene Name
CBY1 ARB1 C22orf2 CBY PGEA1 HRIHFB2025
Immunogen
Synthesized peptide derived from human CBY1 AA range: 71-121
Specificity
This antibody detects endogenous levels of CBY1 at Human/Mouse/Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.,miscellaneous:Chibby is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.,similarity:Belongs to the chibby family.,subcellular location:Nuclear, in a punctate manner. Also found in the trans-Golgi.,subunit:Homodimer; interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of beta-catenin.,tissue specificity:Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Signif
