Reactive species
Human;Mouse
Antibody type
Polyclonal Antibody
Protein name
BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
BAG2 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008],
Function
function:Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.,similarity:Contains 1 BAG domain.,subunit:Binds to the ATPase domain of HSP70/HSC chaperones.,
