Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Gene Name
SETDB2 C13orf4 CLLD8 KMT1F
Protein name
Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.43) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SETB2 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
SET domain bifurcated 2(SETDB2) Homo sapiens This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
Function
catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,function:Probable histone methyltransferase.,similarity:Belongs to the histone-lysine methyltransferase family.,similarity:Contains 1 MBD (methyl-CpG-binding) domain.,similarity:Contains 1 pre-SET domain.,similarity:Contains 1 SET domain.,tissue specificity:Ubiquitous. Highest expression in heart, testis and ovary.,
