Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Protein name
Chromodomain Y-like protein (CDY-like) (EC 2.3.1.48)
Immunogen
Synthesized peptide derived from human protein . at AA range: 60-140
Specificity
CDYL1 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,function:Acts as repressor of transcription (By similarity). Has histone acetyltransferase activity, with a preference for histone H4.,miscellaneous:Interaction with HDAC1 or HDAC2 prevents coenzyme A binding.,similarity:Contains 1 chromo domain.,subunit:Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain.,tissue specificity:Ubiquitous. Expressed at moderate levels in all tissues examined.,
