Reactive species
Human;Rat;Mouse
Antibody type
Polyclonal Antibody
Gene Name
SPEG APEG1 KIAA1297
Protein name
Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SPEG Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Along with the desmin gene, expression of this gene may be controlled by the desmin locus control region. Mutations in this gene are associated with centronuclear myopathy 5. [provided by RefSeq, Jun 2016],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.,induction:Isoform 3 is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.,miscellaneous:Expression is under the tight control of the locus control region (LCRs).,PTM:May be autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 protein kinase domains.,similarity:Contains 9 Ig-like (immunoglobulin-like) domains.,subunit:Isoform 3 is found as a monomer or homodimer.,tissue specificity:Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as
