Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Protein name
Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SPAG5 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008],
Function
function:Necessary for normal spindle formation during mitosis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subcellular location:In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase. Detected on kinetochores of chromosomes that have congressed.,subunit:Homodimer, with a globular head domain and a long stalk. Homo-oligomer; the globular head domains associate, resulting in aster-like structures. Binds to microtubules in the mitotic spindle.,tissue specificity:Highly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon.,
