Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Gene Name
SPTBN4 KIAA1642 SPTBN3
Protein name
Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SPTN4 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
similarity:Belongs to the spectrin family.,similarity:Contains 1 PH domain.,similarity:Contains 18 spectrin repeats.,similarity:Contains 2 CH (calponin-homology) domains.,tissue specificity:Abundantly expressed in brain and pancreatic islets.,
