Reactive species
Human;Mouse
Antibody type
Polyclonal Antibody
Gene Name
SH2D3C NSP3 UNQ272/PRO309/PRO34088
Protein name
SH2 domain-containing protein 3C (Novel SH2-containing protein 3)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SH2D3 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
Function
function:Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 1 SH2 domain.,subcellular location:Associated with the membrane when EGF-stimulated. Found at ruffling membranes.,subunit:Interacts with PTK2B. Isoform 2 interacts with BCAR1/CAS and NEDD9/HEF1.,tissue specificity:Ubiquitously expressed.,
