Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Gene Name
RASGRP3 GRP3 KIAA0846
Protein name
Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1)
Immunogen
Synthesized peptide derived from human protein . at AA range: 90-170
Specificity
GRP3 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
RAS guanyl releasing protein 3(RASGRP3) Homo sapiens Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008],
Function
function:Guanine nucleotide exchange factor (GEF) for Ras and Rap1.,similarity:Belongs to the RASGRP family.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 2 EF-hand domains.,
