Reactive species
Human;Mouse
Antibody type
Polyclonal Antibody
Gene Name
RAB11FIP5 GAF1 KIAA0857 RIP11
Protein name
Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11)
Immunogen
Synthesized peptide derived from human protein . at AA range: 570-650
Specificity
RFIP5 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
disease:Antibodies against RIP11 are found in sera from patients with systemic lupus erythematosus (SLE) or Sjoegren syndrome (SS), and in the sera from mothers of children with neonatal lupus erythematosus (NLE).,domain:Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg(2+) rather than Ca(2+).,function:Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane.,PTM:Phosphorylated on serine and threonine residues.,similarity:Contains 1 C2 domain.,subunit:Forms an heterooligomeric complex with RAB11FIP4. Binds NAPG and SSA2. Binds RAB11A that has been activated by GTP binding.,tissue specificity:Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.,
Function
disease:Antibodies against RIP11 are found in sera from patients with systemic lupus erythematosus (SLE) or Sjoegren syndrome (SS), and in the sera from mothers of children with neonatal lupus erythematosus (NLE).,domain:Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg(2+) rather than Ca(2+).,function:Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane.,PTM:Phosphorylated on serine and threonine residues.,similarity:Contains 1 C2 domain.,subunit:Forms an heterooligomeric complex with RAB11FIP4. Binds NAPG and SSA2. Binds RAB11A that has been activated by GTP binding.,tissue specificity:Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.,
