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NR0B2 Polyclonal Antibody

Product code: YP-Ab-05872
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Product introduction

Reactive species
Human;Rat;Mouse
Applications
WB;ELISA
Antibody type
Polyclonal Antibody
Gene Name
NR0B2 SHP
Protein name
Nuclear receptor subfamily 0 group B member 2 (Orphan nuclear receptor SHP) (Small heterodimer partner)
Dalton(DA)
28kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 30-110
Specificity
NR0B2 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Stockpile
-20°C/1 year
Other name
Background
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008],
Function
disease:Defects in NR0B2 may be associated with early-onset obesity [MIM:601665].,function:Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts.,similarity:Belongs to the nuclear hormone receptor family. NR0 subfamily.,subunit:Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A.,tissue specificity:Liver. Low levels of expression were detected in heart and pancreas.,

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