Reactive species
Human;Rat;Mouse
Antibody type
Polyclonal Antibody
Protein name
Neuronal pentraxin-2 (NP2) (Neuronal pentraxin II) (NP-II)
Immunogen
Synthesized peptide derived from human protein . at AA range: 130-210
Specificity
NPTX2 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009],
Function
cofactor:Binds 2 calcium ions per subunit.,function:Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner.,similarity:Contains 1 pentaxin domain.,tissue specificity:Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.,
