Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Protein name
Unconventional myosin-XVIIIb
Immunogen
Synthesized peptide derived from human protein . at AA range: 1680-1760
Specificity
MY18B Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008],
Function
developmental stage:Reaches an expression peak in the third day after induction and remains at similar level during successive myotubule maturation.,disease:Defects in MYO18B are associated with lung cancer. Inactivated in half of the primary lung cancers and cell lines; the causes include deletions, mutations and promoter methylation.,function:May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play an important role as a tumor suppressor in the development of lung cancer.,similarity:Contains 1 IQ domain.,similarity:Contains 1 myosin head-like domain.,subcellular location:Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.,subunit:Homodimer. May int
