Reactive species
Human;Mouse
Antibody type
Polyclonal Antibody
Protein name
Unconventional myosin-XV (Unconventional myosin-15)
Immunogen
Synthesized peptide derived from human protein . at AA range: 2990-3070
Specificity
MYO15 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008],
Function
disease:Defects in MYO15A are the cause of non-syndromic sensorineural deafness autosomal recessive type 3 (DFNB3) [MIM:600316]. DFNB3 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,function:Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles.,similarity:Contains 1 FERM domain.,similarity:Contains 1 myosin head-like domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 MyTH4 domains.,similarity:Contains 3 IQ domains.,subcellular location:Localizes to ste
