Reactive species
Human;Rat;Mouse
Antibody type
Polyclonal Antibody
Protein name
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (hMAdCAM-1)
Immunogen
Synthesized peptide derived from human protein . at AA range: 260-340
Specificity
MADCA Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008],
Function
alternative products:Additional isoforms seem to exist,function:Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.,polymorphism:The number of repeats in the mucin domain varies between 5 and 8 repeats.,PTM:The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.,similarity:Contains 2 Ig-like (immunoglobulin-like) domains.,subunit:Homodimer.,tissue specificity:Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small int
