Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Protein name
Low-density lipoprotein receptor-related protein 12 (LRP-12) (Suppressor of tumorigenicity 7 protein)
Immunogen
Synthesized peptide derived from human protein . at AA range: 90-170
Specificity
LRP12 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],
Function
function:Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.,similarity:Belongs to the LDLR family.,similarity:Contains 2 CUB domains.,similarity:Contains 5 LDL-receptor class A domains.,subunit:May interact with GNB2L1, MADHIP and ITGB1BP3.,tissue specificity:Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.,
