Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Protein name
Estradiol 17-beta-dehydrogenase 12 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (EC 1.3.1.-)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DHB12 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011],
Function
catalytic activity:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.,domain:The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.,function:Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.,pathway:Lipid metabolism; fatty acid biosynthesis.,pathway:Steroid biosynthesis; estrogen biosynthesis.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.,tissue specificity:Expressed in most tissues tested. Highly expressed in the ovary
