Reactive species
Human;Rat
Antibody type
Polyclonal Antibody
Protein name
Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CBPD Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
carboxypeptidase D(CPD) Homo sapiens The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Releases C-terminal Arg and Lys from polypeptides.,cofactor:Binds 2 zinc ions per subunit.,domain:There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.,similarity:Belongs to the peptidase M14 family.,tissue specificity:Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.,
