Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Gene Name
CADPS2 CAPS2 KIAA1591
Protein name
Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CAPS2 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
calcium dependent secretion activator 2(CADPS2) Homo sapiens This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009],
Function
domain:The PH domain is essential for regulated exocytosis and binds phospholipids.,function:Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles.,PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Chimera.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 1 C2 domain.,similarity:Contains 1 MHD1 (MUNC13 homology domain 1) domain.,similarity:Contains 1 PH domain.,subcellular location:Membrane-associated to vesic
