Reactive species
Human;Mouse
Antibody type
Polyclonal Antibody
Protein name
Epidermal growth factor receptor kinase substrate 8
Immunogen
Synthesized peptide derived from human protein . at AA range: 130-210
Specificity
EPS8 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008],
Function
domain:The SH3 domain mediates interaction with SHB.,function:Upon binding to EGF receptor enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.,PTM:Phosphorylated by several receptor tyrosine kinases.,similarity:Belongs to the EPS8 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer (By similarity). Interacts with BAIAP2. Interacts with SHB.,tissue specificity:Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.,
