Reactive species
Human;Mouse
Antibody type
Polyclonal Antibody
Protein name
Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1)
Immunogen
Synthesized peptide derived from human protein . at AA range: 1-80
Specificity
PLSL Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008],
Function
function:Actin-binding protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia.,PTM:Phosphorylated.,PTM:The N-terminus is blocked.,similarity:Contains 2 actin-binding domains.,similarity:Contains 2 EF-hand domains.,similarity:Contains 4 CH (calponin-homology) domains.,subunit:Monomer.,tissue specificity:Restricted to the spleen and other lymph node-containing organs. Expressed in neutrophils, monocytes, B lymphocytes, and myeloid cells.,
